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KMID : 0388220110180010011
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Journal of the Korean Rheumatism Association
2011 Volume.18 No. 1 p.11 ~ p.18
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Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages
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Ji Jong-Dae
Kim Tae-Hwan
Lee Bitnara
Choi Seong-Jae
Lee Young-Ho
Song Gwan-Gyu
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Abstract
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Objective: To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB) CD14+ osteoclast precursors.
Methods: The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis, the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR.
Results: Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis- related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors.
Conclusion: The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors.
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KEYWORD
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Rheumatoid arthritis, Synovial osteoclast precursors, Osteoclastogenesis
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